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TREATMENTS · OVULATION INDUCTION
Ovulation tablets work when a scan checks them.
Ovulation induction uses tablets, usually letrozole, to help one follicle grow and release an egg. Scans show whether it worked, so intercourse or IUI can be timed to the day.
- Tablets for about 5 days
- 2 or 3 follicle scans a cycle
- Letrozole first in PCOS
- A set number of cycles
- Tablets — A few days early in the cycle
- Follicle — One grows ahead of the rest
- Scan — Measures size and the lining
- Ovulation — Timed intercourse or IUI
Is this right for you?
Do any of these sound like you?
Worth discussing if
- Periods more than 35 days apart, or none
- Diagnosed with PCOS
- Ovulation kits never turn positive
- Months of tablets with no scans
- Tubes open and sperm test normal
PROBABLY NOT YET
Ovulation tablets without a scan are a guess. So is treating the wrong thing.
- Your periods are regular and you are still not pregnant. The cause is often elsewhere.
- Your partner has not had a semen analysis yet. Tablets can’t fix a sperm problem.
- You are hoping a higher dose will help. More tablets do not mean more chance.
- Your thyroid and prolactin have not been checked yet. Those are ruled out first.
Regular periods but still not pregnant? The cause is often elsewhere. Start with a check for both of you.
01What is ovulation induction?
Ovulation induction is treatment with tablets or low-dose injections that helps the ovary grow one mature follicle and release an egg.
It is for women who ovulate rarely or not at all, most often because of PCOS. It can also help women with very irregular cycles for other reasons, once thyroid and prolactin problems are ruled out. The aim is modest on purpose: one egg, released at a time we can see.
02Letrozole or clomiphene: which is better?
For women with PCOS who are not ovulating, international guidelines recommend letrozole as the first tablet, because it leads to more live births than clomiphene.
Letrozole briefly lowers oestrogen, so the brain releases more of the hormone that grows follicles. Clomiphene can thin the womb lining in some women; letrozole usually does not. Clomiphene is still an option when letrozole doesn't suit you. Both are taken for about 5 days early in the cycle.
03Why do I need scans when I'm taking tablets?
Scans show whether the tablets worked: how many follicles grew, how big they are, and whether the lining is ready.
Without a scan, nobody knows if you ovulated, when, or whether three follicles grew instead of one. That is how months pass on tablets with no answer. We usually scan 2 or 3 times around day 8 to 14, and adjust the dose next cycle from what we see.
Ovulation tablets without a scan are a guess. If you've taken them for months with no follicle scans, that is the first thing to fix, before anything bigger. (Jananam fertility team [CONFIRM: Dr Vani to approve wording; not yet a quoted position])
04Timed intercourse or IUI?
If the sperm test is normal and at least one tube is open, timed intercourse on the days the scan shows is usually the first step.
IUI is added when the sperm count is mildly low, intercourse is difficult, or timed cycles haven't worked. Sometimes a trigger injection is used to release the egg at a known time. [CONFIRM: Jananam's routine] The choice depends on age, sperm results, tubes and how long you've tried.
How IUI works05How many cycles of letrozole should I try?
Usually up to about six cycles in which you ovulate, and fewer if you are older or also need IUI. [CONFIRM: Dr Vani's limit]
If you ovulate and are not pregnant after those cycles, more of the same rarely helps. If you don't ovulate even at the right dose, the plan changes sooner: low-dose injections, IUI, or IVF. The limit is agreed at your first visit, not after a year of tablets.
06Does ovulation induction cause twins?
It can, because tablets sometimes grow more than one follicle, and that is the main risk of ovulation induction.
Twins carry real risks for mother and babies, including early birth. Scans are how we see it coming: if too many follicles grow, we advise you not to try that month and adjust the dose next time. Hot flushes, headaches and bloating are common, mild side effects.
An ovulation induction cycle, step by step.
- 1
Tests for both of you Before the first cycle
Semen analysis, pelvic scan, blood tests (thyroid, prolactin, AMH), and a tube check before or early in treatment. [CONFIRM: tube check timing]
- 2
Start of the cycle Day 2 or 3 of your period
A baseline scan checks the ovaries are quiet. With no periods, a short course of tablets can bring one on first.
- 3
Tablets Usually 5 days, from day 2 or 3
Letrozole (or clomiphene) at the dose we set for you. Don't change it yourself.
- 4
Follicle scans Around day 8 to 14, 2 or 3 short scans
We measure the follicle and the lining. Too many follicles means we advise not trying this month.
- 5
Timed intercourse or IUI When the follicle is mature
We tell you which days. Sometimes a trigger injection times ovulation more precisely.
- 6
Pregnancy test or review About 2 weeks after ovulation
If negative, we review the scans and adjust the next cycle, or move on if the agreed cycles are done.
Your first visit
Talk
Your cycle pattern, weight, and any tablets you've already taken.
Test
Scan, hormone bloods, semen analysis, and a tube check when needed.
Plan
Letrozole or another option, the dose, and how many cycles before a change.
Treat
Tablets with follicle scans, then timed intercourse or IUI.
Questions patients ask
Still unsure? Ask us on WhatsApp — a real person replies.
How does letrozole help you ovulate?
Letrozole briefly lowers oestrogen, which makes the brain release more follicle-stimulating hormone, so one follicle grows and releases an egg. It is taken as a tablet for about 5 days early in the cycle.
Is letrozole better than clomiphene for PCOS?
Yes, for women with PCOS who are not ovulating, letrozole leads to more live births than clomiphene, which is why guidelines now recommend it first. Clomiphene is still used when letrozole doesn't suit someone.
Can I take letrozole without follicle monitoring?
You can, but you won't know if it worked. Scans show whether you ovulated, when, and whether too many follicles grew, which is the main safety check for twins.
Does letrozole cause twins?
Letrozole can cause twins, because it sometimes grows more than one follicle, although it usually grows one. Scans let us advise you not to try in a month with too many follicles.
What if letrozole doesn't make me ovulate?
If you don't ovulate, the dose is raised in the next cycle or the treatment changes, for example to low-dose injections. If you ovulate but don't conceive after the agreed cycles, IUI or IVF is the next step, depending on your tests and age.
Do I need IVF if I have PCOS?
Most women with PCOS do not need IVF. Weight management, tablets with scans, or low-dose injections restore ovulation for most, and IVF is kept for when these don't work or there is another problem too.
What are the side effects of letrozole?
The common side effects of letrozole are hot flushes, headache, tiredness, dizziness and bloating, and they usually pass after the tablets stop. Tell us about severe pain or a swollen tummy straight away.
In their words, not ours.
Dr. Vani mam is incredibly knowledgeable and took the time to explain everything clearly.
Sources (4)
- Cochrane: Aromatase inhibitors for infertility treatment in women with polycystic ovary syndrome
- ESHRE: International evidence-based guideline for the assessment and management of PCOS (2023)
- Monash Centre for Health Research and Implementation: International PCOS (PMOS) guideline and resources
- NHS: Treatment for infertility
Where to next
Why ovulation stops, and the order treatment goes in.
JOURNALPCOS and trying to conceive
Cycles, weight, tablets: where to actually start.
TREATMENTTREATMENT · When timed cycles need a little more help.
When timed cycles need a little more help.
TESTTube check (HSG or HyCoSy)
Tablets only help if a tube is open.
Months of tablets? Let's check what they did.
Send us your cycle pattern and any scans or tablets you've had. A real person from Dr Vani's team replies on WhatsApp, usually within minutes during clinic hours (Mon to Sat, 9am to 5pm. Sunday closed.).
